Structure-function correlations of snake venom disintegrins.

Juan J Calvete

doi:10.2174/1381612053381783

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Structure-function correlations of snake venom disintegrins.

Juan J Calvete

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Abstract

Disintegrins represent a family of polypeptides released in the venoms of Viperidae and Crotalidae snakes (vipers and rattlesnakes) by the proteolytic processing of multidomain metalloproteinases, which selectively block the function of beta(1) and beta(3) integrin receptors. Research on disintegrins is relevant for understanding the biology of viper venom toxins, but also provides information of new structural determinants involved in integrin recognition that may be useful in both, basic and clinical research. The role of the composition, conformation and concerted dynamics of the integrin inhibitory loop and the C-terminal tail in determining the selective inhibition of integrin receptors is discussed.

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Amino Acid Sequence Animals Crotalid Venoms Disintegrins Humans Integrins Models, Molecular Molecular Sequence Data Platelet Aggregation Inhibitors Snake Venoms Structure-Activity Relationship Viper Venoms Journal Article Research Support, Non-U.S. Gov't Review

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Juan J Calvete. 2005. Structure-function correlations of snake venom disintegrins.. https://doi.org/10.2174/1381612053381783

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