PubMed Health⌕ Search

PubMed · 15794600

Imaging a single-electron quantum dot.

Abstract

Images of a single-electron quantum dot were obtained in the Coulomb blockade regime at liquid He temperatures using a cooled scanning probe microscope (SPM). The charged SPM tip shifts the lowest energy level in the dot and creates a ring in the image corresponding to a peak in the Coulomb-blockade conductance. Fits to the line shape of the ring determine the tip-induced shift of the energy of the electron state in the dot. SPM manipulation of electrons in quantum dots promises to be useful in understanding, building, and manipulating circuits for quantum information processing.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Parisa Fallahi, Ania C Bleszynski, Robert M Westervelt, Jian Huang, Jamie D Walls, Eric J Heller, Micah Hanson, Arthur C Gossard. 2005. Imaging a single-electron quantum dot.. https://doi.org/10.1021/nl048405v

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Capillary-based, serial-loading, parallel microreactor for catalyst screening.

Soluble metal-ligand complexes are useful as catalysts for many organic reactions. The large number of metals and ligands available suggests a combinatorial approach to catalyst discovery. Carrying out reactions in very small (microliter) volumes in capillaries has many advantages in this regard, including material conservation, isolation from the atmosphere, and ease of transport of species by using pressure-induced flow. We have developed a capillary reactor in which separate zones of catalyst and reactants are combined and react. Zones are loaded serially into the capillary reactor from an autosampler, they react in parallel in the capillary reactor (at elevated temperature) and are ejected serially and under computer control for analysis by online GC. Offline analysis following sample collection is also possible. The Stille cross-coupling reaction has been the focus of our recent activity. Known palladium-based precatalysts and phosphine or arsine ligands were screened to validate the approach taken here. The results largely agree with results obtained by traditional organic synthesis, validating the method. The throughput of the nonoptimized system is over two 5-h reactions/h. For example, 40 5-h reactions examining the effect of catalyst loading were performed in 2 9-h runs requiring a total of 2 h of operator time.

Arsenicals↗

A high-efficiency photooxidation reactor for speciation of organic arsenicals by liquid chromatography-hydride generation-ICPMS.

A novel postcolumn photooxidation reactor with remarkably high efficiency was developed. It was installed into a system of liquid chromatography (LC) combined with inductively coupled plasma mass spectrometry (ICPMS) using a hydride generation (HG) technique to enable sensitive speciation of organic arsenicals. An LC eluent was passed into a reaction tube that runs through a low-pressure mercury lamp of a high-efficiency photooxidation (HEPO) reactor. It provided efficient irradiation with vacuum ultraviolet light at 185 nm, which induced oxidative decomposition of persistent organic arsenicals, for example, arsenobetaine, to the final product, arsenate, for an extremely short time, 3.5 s, without using any oxidizing agents. That arsenate was subsequently detectable by HG-ICPMS. In contrast, conventional photooxidation reactors require more than 100 s for completion, even when using a peroxodisulfate solution as an oxidizing agent. Because of the absence of broadening and dilution of the LC-separated peaks caused by mixing with the oxidant solution, the detection limits for 10 arsenic species including the persistent organic arsenicals by the proposed LC-HEPO-HG-ICPMS ranged from 2.3 to 18 ng of As/L, which were about one-tenth as low as those by LC-ICPMS. The proposed method revealed for the first time the occurrence of 20 arsenic species, including the unknown trace species, which were undetectable by LC-ICPMS and LC-HG-ICPMS, in human urine.

Arsenicals↗

Lipopolysaccharide transiently activates THP-1 cell adhesion.

Lipopolysaccharide stimulation of adherent THP-1 cells induces morphological changes that are associated with the reorganization of the actin cytoskeleton. We hypothesized that LPS would also increase THP-1 cell adhesion and sought to determine the signaling mechanisms regulating this response. We show that LPS significantly increases THP-1 cell attachment after 1 h, supporting the idea that LPS can stimulate integrin function. By 4 h however, the number of adherent cells returned to control levels. Importantly, detached cells were determined to be viable by propidium iodide staining, indicating that the increase in cell adhesion was transient. LPS-induced adhesion to fibrinogen- but not fibronectin-coated wells was also transient, suggesting that adhesion reflected beta2 integrin activation. This idea was supported by the fact that LPS-induced adhesion could be blocked by a function-blocking anti-beta2 integrin antibody. Interestingly, the protein tyrosine phosphatase (PTP) inhibitor, phenylarsine oxide, prevented cell detachment. Taken together, these data suggest that LPS-mediated integrin activation is transient and can be regulated by PTP-mediated signaling events.

Arsenicals↗