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PubMed · 15794633

Single DNA molecule detection using nanopipettes and nanoparticles.

Miloslav Karhanek·Jennifer T Kemp·Nader Pourmand·Ronald W Davis·Chris D Webb
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Abstract

Single DNA molecules labeled with nanoparticles can be detected by blockades of ionic current as they are translocated through a nanopipette tip formed by a pulled glass capillary. The nanopipette detection technique can provide not only tools for detection and identification of single DNA and protein molecules but also deeper insight and understanding of stochastic interactions of various biomolecules with their environment.

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Biosensing TechniquesDNAElectrochemistryEquipment DesignEquipment Failure AnalysisGoldMicrofluidic Analytical TechniquesNanotechnologyNanotubesReproducibility of ResultsSensitivity and SpecificityEvaluation StudyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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Miloslav Karhanek, Jennifer T Kemp, Nader Pourmand, Ronald W Davis, Chris D Webb. 2005. Single DNA molecule detection using nanopipettes and nanoparticles.. https://doi.org/10.1021/nl0480464

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