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PubMed · 1579824

[Bronchial hyperreactivity and heart failure].

L Cabanes
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Abstract

A moderate to severe bronchial hyperresponsiveness to methacholine is frequently observed in patients with left heart failure. This bronchial obstruction can be prevented by inhalation of methoxamine, an alpha-adrenergic vasoconstrictor agent. The mechanisms of this hyperresponsiveness include a direct vasodilating effect of methacholine on bronchial vessels and a contractile effect of an airway smooth muscles. This bronchoconstriction is the consequence of a direct effect of methacholine and a contractile effect of an extravased mediators and of an increased vagal tone due to the stimulation a bronchial afferent nerves. The role of bronchial hyperresponsiveness in cardiac dyspnea is currently under investigations.

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AsthmaBronchial HyperreactivityHeart FailureHumansMethacholine CompoundsEnglish AbstractJournal ArticleReview

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L Cabanes. 1992-02-01. [Bronchial hyperreactivity and heart failure].. https://pubmed.ncbi.nlm.nih.gov/1579824/

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