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PubMed · 15803137

Communicating with Hedgehogs.

Joan E Hooper·Matthew P Scott
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Abstract

Signalling by secreted Hedgehog (Hh) proteins is important for the development of many tissues and organs. Damage to components of the Hh signal-transduction pathway can lead to birth defects and cancer. The Hh proteins are distributed in tissues in a gradient, and cells respond to different thresholds of Hh with distinct responses. The cellular machinery that is responsible for the unique molecular mechanisms of Hh signal transduction has been largely conserved during metazoan evolution.

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AnimalsDrosophila ProteinsDrosophila melanogasterEvolution, MolecularHedgehog ProteinsHumansIntercellular Signaling Peptides and ProteinsKinesinsLigandsReceptors, G-Protein-CoupledSignal TransductionTrans-ActivatorsWnt ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Joan E Hooper, Matthew P Scott. 2005. Communicating with Hedgehogs.. https://doi.org/10.1038/nrm1622

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