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PubMed · 15803678

Structural properties of nonionic cyclodextrin colloids in water.

Domenico Lombardo·Alessandro Longo·Raphael Darcy·Antonino Mazzaglia
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Abstract

The amphiphilic character in water of a novel class of chemically modified cyclodextrins has been investigated by means of small-angle X-ray scattering and light scattering. The introduction ofhydrophilic oligo(ethylene glycol) onto the secondary side of heptakis[6-alkylthio-6-deoxy-2-oligo(ethylene glycol)]-beta-cyclodextrins produces an enhanced water solubility of these molecules. Shape and dimensions of the generated micellar aggregates, analyzed in terms of a suitable core-shell model, remain stable in the wide concentration range explored. The highly associative behavior of these macromolecules is evidenced by the very low value of the critical micelle concentration (cmc), which is about 2 orders of magnitude smaller than the cmc usually obtained for traditional surfactant. Despite the complex geometry of this novel macromolecule, shape and dimensions of generated micellar aggregates can be properly described according to the thermodynamic approaches generally used for amphiphilic molecules and block copolymers. Results show how the modulation of hydrophobic and hydrophilic components sensitively influence the structural features of the generated aggregates thus offering the possibility to control molecular organization in a manner similar to that for traditional colloids. For all the classes of the investigated systems, the small micelles have been found in equilibrium with polydisperse large aggregates of entangled micelles. These novel nonionic colloidal systems combine inclusion and transport properties of host macrocycles, such as cyclodextrin, together with the increased stability of colloidal aggregates, and may be of interest for their potential application as innovative drug delivery systems.

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Circular DichroismColloidsCyclodextrinsDrug CarriersDrug Delivery SystemsDrug StabilityEthylene GlycolsLightMicellesModels, StatisticalPolymersProtein BindingScattering, RadiationSolubilitySurface-Active AgentsThermodynamicsTime FactorsWaterX-RaysJournal ArticleResearch Support, Non-U.S. Gov't

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Domenico Lombardo, Alessandro Longo, Raphael Darcy, Antonino Mazzaglia. 2004-02-17. Structural properties of nonionic cyclodextrin colloids in water.. https://doi.org/10.1021/la035370q

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