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PubMed · 15805601

Likelihood-enhanced fast translation functions.

Airlie J McCoy·Ralf W Grosse-Kunstleve·Laurent C Storoni·Randy J Read
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Abstract

This paper is a companion to a recent paper on fast rotation functions [Storoni et al. (2004), Acta Cryst. D60, 432-438], which showed how a Taylor-series expansion of the maximum-likelihood rotation function leads to improved likelihood-enhanced fast rotation functions. In a similar manner, it is shown here how linear and quadratic Taylor-series expansions and least-squares approximations of the maximum-likelihood translation function lead to likelihood-enhanced translation functions, which can be calculated by FFT and which are more sensitive to the correct translation than the traditional correlation-coefficient fast translation function. These likelihood-enhanced translation targets for molecular-replacement searches have been implemented in the program Phaser using the Computational Crystallography Toolbox (cctbx).

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Bacterial ProteinsCrystallographyElapid VenomsLeast-Squares AnalysisLikelihood FunctionsSoftwarebeta-LactamasesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Airlie J McCoy, Ralf W Grosse-Kunstleve, Laurent C Storoni, Randy J Read. 2005-03-24. Likelihood-enhanced fast translation functions.. https://doi.org/10.1107/s0907444905001617

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