Mitochondrial nitric oxide synthase.

Pedram Ghafourifar; Enrique Cadenas

doi:10.1016/j.tips.2005.02.005

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PubMed · 15808343

Mitochondrial nitric oxide synthase.

Pedram Ghafourifar·Enrique Cadenas

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Abstract

Mitochondria produce nitric oxide (NO) through a Ca(2+)-sensitive mitochondrial NO synthase (mtNOS). The NO produced by mtNOS regulates mitochondrial oxygen consumption and transmembrane potential via a reversible reaction with cytochrome c oxidase. The reaction of this NO with superoxide anion yields peroxynitrite, which irreversibly modifies susceptible targets within mitochondria and induces oxidative and/or nitrative stress. In this article, we review the current understanding of the roles of mtNOS as a crucial biochemical regulator of mitochondrial functions and attempt to reconcile apparent discrepancies in the literature on mtNOS.

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Animals Humans Mitochondria Nitric Oxide Nitric Oxide Synthase Oxidative Stress Oxygen Consumption Journal Article Review

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Pedram Ghafourifar, Enrique Cadenas. 2005. Mitochondrial nitric oxide synthase.. https://doi.org/10.1016/j.tips.2005.02.005

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