Antimalarial benzo[c]phenanthridines.

James M Nyangulu; Samantha L Hargreaves; Susan L Sharples; Simon P Mackay; Roger D Waigh; Olivier Duval; Eddie K Mberu; William M Watkins

doi:10.1016/j.bmcl.2005.02.074

PubMed · 15808457

Antimalarial benzo[c]phenanthridines.

James M Nyangulu·Samantha L Hargreaves·Susan L Sharples·Simon P Mackay·Roger D Waigh·Olivier Duval·Eddie K Mberu·William M Watkins

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Abstract

Analogues of the antimalarial alkaloid nitidine have been prepared with high potency against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. Simple modifications, using an established synthetic route, resulted in an analogue with IC(50) below 5ng/mL against a chloroquine-sensitive strain of P. falciparum. N-Ethylethoxidine had IC(50) below 30ng/mL against both chloroquine-sensitive and chloroquine-resistant strains of P. falciparum.

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Animals Antimalarials Humans Microbial Sensitivity Tests Netropsin Phenanthridines Plasmodium falciparum Comparative Study Journal Article

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James M Nyangulu, Samantha L Hargreaves, Susan L Sharples, Simon P Mackay, Roger D Waigh, Olivier Duval, Eddie K Mberu, William M Watkins. 2005-04-15. Antimalarial benzo[c]phenanthridines.. https://doi.org/10.1016/j.bmcl.2005.02.074

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