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Detection of cortical activation with time-resolved diffuse optical methods.

Bruno Montcel·Renee Chabrier·Patrick Poulet
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Abstract

Simulations based on diffusion theory that use a finite-element method and rely on an magnetic resonance imaging head model suggest that time-resolved diffuse optical techniques could provide information about the depth at which variations in perfusion take place and improve the detection of cortical activation. Experimental investigations were performed with sequentially driven picosecond laser diodes and an eight-channel time-correlated single-photon-counting detection system. The experimental results obtained for activation in the motor cortex, and for the Valsalva maneuver, confirm our assumptions and are in good agreement with the simulated data.

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AlgorithmsBrain MappingCerebral CortexComputer SimulationEvoked Potentials, MotorHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingModels, NeurologicalReproducibility of ResultsSensitivity and SpecificitySpectroscopy, Near-InfraredTomography, OpticalEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov'tValidation Study

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Bruno Montcel, Renee Chabrier, Patrick Poulet. 2005-04-01. Detection of cortical activation with time-resolved diffuse optical methods.. https://doi.org/10.1364/ao.44.001942

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