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A kinase for light and time.

Jennifer Loros
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Abstract

The eukaryotic filamentous fungus Neurospora crassa has proven to be a dependable model system for the analysis of light-regulated gene expression and circadian rhythmicity. The molecular basis of the core circadian clock is a transcription/translation-based feedback loop in which a heterodimer of the white-collar 1 (WC-1) and white-collar 2 (WC-2) proteins act as a transcription factor to promote expression of the negative elements in the clock, frq mRNA and FRQ protein. Additionally, WC-1 is a flavoprotein that acts as the primary responder to environmental light and, in conjunction with WC-2, is the major photoreceptor for the clock as well as other light-regulated processes. Protein kinase C acts as a light-dependent regulator of the WC-1 protein.

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Biological ClocksCircadian RhythmDNA-Binding ProteinsFungal ProteinsGene Expression RegulationLightModels, BiologicalNeurospora crassaProtein Kinase CTranscription FactorsJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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Jennifer Loros. 2005. A kinase for light and time.. https://doi.org/10.1111/j.1365-2958.2005.04546.x

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