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PubMed · 15815733

[COX-2 inhibitors--one step forward and two steps back].

Sigurd Evensen·Olav Spigset·Lars Slørdal
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Abstract

BACKGROUND: Selective cyclooxygenase-2 (COX-2) inhibitors are widely used. They have no advantages in terms of efficacy, and it is not documented that they cause fewer adverse effects than conventional NSAIDs. MATERIAL AND METHODS: The adverse effects of rofecoxib, celecoxib and other NSAIDs are reviewed. Relevant literature was identified on Medline and in the reference lists in key articles. RESULTS: Rofecoxib and the novel COX-2 inhibitors etoricoxib and valdecoxib have a higher degree of COX-2 selectivity than traditional NSAIDs. Celecoxib is less COX-2 selective and appears to be similar to diclofenac. Rofecoxib induces thromboembolic adverse effects more frequently than conventional NSAIDs. INTERPRETATION: The cardiovascular problems conferred by rofecoxib are probably a class effect and thus inducible by other selective COX-2 inhibitors. Pending comprehensive safety data, caution is warranted regarding the use of these drugs.

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Anti-Inflammatory Agents, Non-SteroidalCardiovascular DiseasesCelecoxibCyclooxygenase InhibitorsGastrointestinal DiseasesHumansLactonesPyrazolesRisk FactorsSulfonamidesSulfonesEnglish AbstractJournal ArticleReview

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Sigurd Evensen, Olav Spigset, Lars Slørdal. 2005-04-07. [COX-2 inhibitors--one step forward and two steps back].. https://pubmed.ncbi.nlm.nih.gov/15815733/

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