PubMed · 15816708
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Annick Touba. 2005. [The liberal struggle to create order].. https://pubmed.ncbi.nlm.nih.gov/15816708/
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The Mediterranean population of tomato leaf curl New Delhi virus (ToLCNDV-ES) is characterized by a high genetic uniformity, distinguishing it from its Asian counterparts. ToLCNDV-ES is thought to have a monophyletic origin, likely resulting from a single recombination event, prior to its spread throughout the Mediterranean region. Following its first detection in southeastern France in 2020, ToLCNDV-ES re-emerged in France in 2022. Our analysis based on advanced long-read sequencing, circular DNA profiling, and phylogeny indicates both local persistence of French ToLCNDV-ES and multiple independent introduction events. Signatures of positive selection were identified in French ToLCNDV-ES populations, whereas no clear evidence of recombination was found. Bayesian time-structured phylogenetic analyses suggest that introductions in France occurred between 2018 and 2021 from the major ToLCNDV-ES clade, while several Italian ToLCNDV-ES isolates diverged prior to the virus introduction in the Mediterranean basin. Overall, this study demonstrates the value of an optimized long-read sequencing approach for resolving circular DNA virus diversity, and sheds light on the complex evolutionary history of ToLCNDV-ES in the Mediterranean Basin, particularly in southeastern France.
OBJECTIVES: To describe the course of employee-individual clinical status with respect to upper limb musculoskeletal disorders (UL-MSDs), epidemiological surveillance of UL-MSDs was implemented for three consecutive years at a household appliance assembly company. METHODS: A standardized clinical examination guide was used to survey UL-MSDs of employees seen in annual consultation. Recorded data included eight specific UL-MSDs as well as the main sociodemographic characteristics of employees. Univariate and multivariate analysis were performed. Significance was defined as P<0.05. All statistical analysis were performed with Statgraphics (version 5.1) software. RESULTS: During three consecutive years, 459 employees were seen in the occupational medicine consultation. The annual prevalence of UL-MSD cases was 20.2% in 2000, 21.7% in 2001 and 24.0% in 2002. In fact, this relative stability conceals significant renewal of the population suffering from UL-MSDs with time, illustrated by both a high rate of annual incidence of cases (9.8 and 13.5% in 2001 and 2002, respectively) and a high rate of annual recoveries (37.0 and 44.3% in 2001 and 2002, respectively). CONCLUSION: Factors governing variation in individual clinical status of employees with respect to UL-MSDs and their interactions remain little known and open up interesting research prospects.
Dr. Nicole Vaysse's exceptional achievements in pancreatic research shifted the paradigm in hormonal regulation of pancreatic function. Her observations became a starting point for many investigators in this field. In this article, Dr. Vaysse shares with Pancreatology her experience as a pancreatic researcher and gives advice to young investigators starting in this area.