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PubMed · 15817391

C1, see them all.

Christine Hall·Louis Lim·Thomas Leung
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Abstract

Recent structural analysis of crystalline beta2-chimaerin shows the central protein kinase C-like, diacylglycerol (DAG)-binding C1 domain to be masked by its intramolecular interactions with the N-terminal SH2 and GAP domains, and linker regions. A mechanism of activation has been derived from modelling of a GAP-Rac GTPase complex--the auto-inhibitory constraints are released via membrane engagement, unmasking the C1 domain to enable DAG binding and subsequent GAP stimulation of Rac GTPase catalytic activity.

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AnimalsDiglyceridesHumansNeoplasm ProteinsPhylogenyProtein Conformationrac GTP-Binding ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Christine Hall, Louis Lim, Thomas Leung. 2005. C1, see them all.. https://doi.org/10.1016/j.tibs.2005.02.003

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