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Serotonin and aggression.

Berend Olivier
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Abstract

The neurotransmitter serotonin (5-HT) has been implicated in the modulation of aggression in animals and humans. A longstanding dogma that aggression and serotonergic activity are inversely related has to be abandoned in light of many new findings. Trait and state aggression are differentially regulated by the 5-HT system and different 5-HT receptors seem to be involved. Of the 14 different 5-HT receptors, the 5-HT(1B) receptor, particularly the postsynaptically located 5-HT(1B) heteroreceptor, plays a highly selective role in the modulation of offensive aggression. We are still far from understanding the complex role played by the serotonergic system in the modulation of a complex set of behaviors like aggression.

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AggressionAnimalsDisease Models, AnimalHumansReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT1BSerotoninSocial Behavior DisordersJournal ArticleReview

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Berend Olivier. 2004. Serotonin and aggression.. https://doi.org/10.1196/annals.1330.022

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