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Thermosensitive biodegradable polydepsipeptide.

Yuichi Ohya·Megumi Toyohara·Mitsuhiro Sasakawa·Hidetoshi Arimura·Tatsuro Ouchi
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Abstract

A poly(N-isopropylacrylamide) (PNIPAAm)-like biodegradable thermosensitive polydepsipeptide, poly[Glc-Asn(N-isopropyl)], was synthesized by introducing an isopropyl amide group into poly[Glc-Asn]. Poly[Glc-Asn(N-isopropyl)] was degraded in vitro by cleavage of the ester bonds in the main chain in water at room temperature. The non-toxic nature of the polymer and its degradation products, coupled with a cloud point at 29 degrees C in water, make this polymer attractive for biomedical implant applications.

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AnimalsBiocompatible MaterialsBiodegradation, EnvironmentalCell SurvivalCells, CulturedDepsipeptidesFibroblastsMicePeptidesTemperatureJournal ArticleResearch Support, Non-U.S. Gov't

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Yuichi Ohya, Megumi Toyohara, Mitsuhiro Sasakawa, Hidetoshi Arimura, Tatsuro Ouchi. 2005-04-19. Thermosensitive biodegradable polydepsipeptide.. https://doi.org/10.1002/mabi.200400221

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