BRCA2: breaks, mistakes and failed separations.

Teresa M Rudkin; William D Foulkes

doi:10.1016/j.molmed.2005.02.003

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BRCA2: breaks, mistakes and failed separations.

Teresa M Rudkin·William D Foulkes

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Abstract

BRCA2 was identified in 1995, one year after BRCA1. In terms of knowledge of the function of its product, BRCA2 has remained the less well-characterised gene. Both BRCA1 and BRCA2 are closely implicated in the repair of double-strand breaks in DNA by homologous recombination, but beyond that a function for BRCA2 has been hard to discern. A recent study has extended the function of BRCA2 to the regulation of cell cleavage and separation. Other groups have also shown how BRCA2, RAD51 and DSS1 co-exist in a ménage à trois and how the disruption of any one of the three cohabitants can have disastrous consequences for the cell.

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Teresa M Rudkin, William D Foulkes. 2005. BRCA2: breaks, mistakes and failed separations.. https://doi.org/10.1016/j.molmed.2005.02.003

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