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Neural integrator function in murine CACNA1A mutants.

John S Stahl·Robert A James
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Abstract

Time constants of gaze holding are shortened in rocker and tottering mice, two strains whose cerebellar dysfunction stems from genetic alterations of the P/Q calcium channel. The finding suggests that in mice as in primates, the cerebellum contributes to the function of the neural integrator. Studying CACNA1A mutants may elucidate how cerebellar signals support gaze holding.

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AnimalsCalcium Channels, N-TypeCalcium Channels, P-TypeCalcium Channels, Q-TypeCerebellar AtaxiaCerebellumFixation, OcularMiceMutationPrimatesSignal TransductionJournal ArticleResearch Support, N.I.H., Extramural

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John S Stahl, Robert A James. 2005. Neural integrator function in murine CACNA1A mutants.. https://doi.org/10.1196/annals.1325.072

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