[PPARs target genes].

Ichiro Takada; Shigeaki Kato

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PubMed · 15828222

[PPARs target genes].

Ichiro Takada·Shigeaki Kato

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Abstract

PPAR(alpha, beta/delta, gamma) are ligand-dependent nuclear receptors and regulate homeostasis, cell proliferation/differentiation and associate with hypolipidemia, atherosclerosis, diabetes, and obesity. Through heterodimerization with retinoid X receptors (RXRs), PPARs bind the same consensus response element, formed by a direct repeat of two AGGTCA hexamers separated by one base. Recently, many PPAR direct and indirect target genes have been reported. Here, we summarize the PPAR direct/indirect target genes, and their functions related to lipid metabolism, adipocyte differentiation.

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Animals Fatty Acids Gene Expression Regulation Lipid Metabolism Peroxisome Proliferator-Activated Receptors Receptors, Cytoplasmic and Nuclear English Abstract Journal Article Review

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Ichiro Takada, Shigeaki Kato. 2005. [PPARs target genes].. https://pubmed.ncbi.nlm.nih.gov/15828222/

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