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Depth-resolved low-coherence enhanced backscattering.

Young L Kim·Yang Liu·Vladimir M Turzhitsky·Ramesh K Wali·Hemant K Roy·Vadim Backman
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Abstract

The phenomenon of enhanced backscattering (also known as coherent backscattering), an object of substantial scientific interest, has awaited application to tissue optics for the past two decades. Here we demonstrate, for the first time to our knowledge, depth-resolved spectroscopic elastic light scattering measurements in tissue by use of low-coherence enhanced backscattering (LEBS). We achieve the depth resolution by exploiting the nature of the LEBS peak that contains information about a wide range of tissue depths. We further demonstrate that depth-resolved LEBS spectroscopy has the potential to identify the origin of precancerous transformations in the colon at an early, previously undetectable stage.

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AdenomaAnimalsColonic NeoplasmsImage EnhancementImaging, Three-DimensionalLightMalePhantoms, ImagingPrecancerous ConditionsRatsRats, Inbred F344Reproducibility of ResultsScattering, RadiationSensitivity and SpecificityTomography, Optical CoherenceEvaluation StudyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Validation Study

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Young L Kim, Yang Liu, Vladimir M Turzhitsky, Ramesh K Wali, Hemant K Roy, Vadim Backman. 2005-04-01. Depth-resolved low-coherence enhanced backscattering.. https://doi.org/10.1364/ol.30.000741

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