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EGF receptor inhibition: attacks on multiple fronts.

Stevan R Hubbard
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Abstract

The epidermal growth factor receptor (EGFR) drives tumor growth in a subset of human epithelial carcinomas. A crystallographic study by Li et al. in this issue of Cancer Cell provides the molecular basis for inhibition of EGFR by cetuximab (Erbitux), a monoclonal antibody that has been approved by the Food and Drug Administration as a therapeutic for advanced-stage colorectal cancers. Cetuximab targets one of the ligand binding domains of EGFR, thus preventing ligand activation of the receptor.

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Antibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntigen-Antibody ComplexAntineoplastic AgentsCetuximabErbB ReceptorsHumansModels, MolecularProtein Structure, QuaternaryProtein Structure, TertiaryReceptor AggregationReceptor Protein-Tyrosine KinasesErb-b2 Receptor Tyrosine KinasesTrastuzumabJournal Article

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Stevan R Hubbard. 2005. EGF receptor inhibition: attacks on multiple fronts.. https://doi.org/10.1016/j.ccr.2005.04.004

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