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Cyclin E in normal and neoplastic cell cycles.

Harry C Hwang·Bruce E Clurman
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Abstract

Cyclin E-Cdk2 has long been considered an essential and master regulator of progression through G1 phase of the cell cycle. Although recent mouse models have prompted a rethinking of cyclin E function in mammals, it remains clear that cyclin E impacts upon many processes central to cell division. Normal cells maintain strict control of cyclin E activity, and this is commonly disrupted in cancer cells. Moreover, cyclin E deregulation is thought to play a fundamental role in tumorigenesis. In this review, we discuss the regulation and functions of cyclin E in normal and neoplastic mammalian cells.

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AnimalsCell CycleCyclin ECyclin-Dependent KinasesHumansMiceMice, KnockoutNeoplasmsPhosphorylationJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Harry C Hwang, Bruce E Clurman. 2005-04-18. Cyclin E in normal and neoplastic cell cycles.. https://doi.org/10.1038/sj.onc.1208613

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