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PubMed · 15853660

Novel insights into c-Src.

O Alper·E T Bowden
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Abstract

Since identifying a transmissible agent responsible for tumorigenesis in chickens, the v-Src oncogene, significant progress has been made in determining the functions of its cellular homologue. c-Src is the product of the SRC gene and has been found both over-expressed and highly activated in a number of human cancers. In fact the relationship between c-Src activation and cancer progression is significant. Furthermore c-Src may play a role in the acquisition of the invasive and metastatic phenotype. In this review we will summarize some of the latest evidence for the role of c-Src in tumorigenesis and particularly in human tumor progression. In this review, specifically, we will address growth signals, adhesion, migration, invasion, angiogenesis and functional genomics.

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AnimalsDisease ProgressionGenes, srcHumansNeoplasmsNeovascularization, PathologicProto-Oncogene Proteins pp60(c-src)Journal ArticleReview

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O Alper, E T Bowden. 2005. Novel insights into c-Src.. https://doi.org/10.2174/1381612053507576

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