Post-assembly peptide modifications by chemical methods.

Sambasivarao Kotha; Kakali Lahiri

doi:10.2174/0929867053507333

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Post-assembly peptide modifications by chemical methods.

Sambasivarao Kotha·Kakali Lahiri

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Abstract

The demand for peptide drugs is increasing and in this context, "post-assembly (or post-translational) peptide modification strategies" by chemical manipulation of intact oligo-peptides has provided several analogues. Compounds prepared by this method are useful therapeutic molecules for structure activity studies. Herein, we describe various chemical methods such as cross-coupling reactions, cycloaddition reactions, radical reactions and ring-closing metathesis reactions that are useful for post-translational peptide modifications.

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Molecular Structure Oligopeptides Pharmaceutical Preparations Journal Article Research Support, Non-U.S. Gov't Review

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Sambasivarao Kotha, Kakali Lahiri. 2005. Post-assembly peptide modifications by chemical methods.. https://doi.org/10.2174/0929867053507333

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