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PubMed · 1585455

Closed circular DNA as a probe for protein-induced structural changes.

J H White·R M Gallo·W R Bauer
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Abstract

Biological systems are replete with examples of DNA formed into a closed loop structure, either alone or in close association with proteins. Such closed circular DNA molecules are subject to a topological constraint that modifies, often in a major way, the structure and reactivity of the DNA. The topological constraint also permits closed circular DNAs to be used as analytical tools to learn about the structure of DNA-protein complexes.

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DNA ProbesDNA, CircularDNA-Binding ProteinsDNA-Directed RNA PolymerasesEscherichia coliStructure-Activity RelationshipJournal ArticleReview

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J H White, R M Gallo, W R Bauer. 1992. Closed circular DNA as a probe for protein-induced structural changes.. https://doi.org/10.1016/0968-0004(92)90417-8

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