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Association mapping and fine mapping with TreeLD.

Sebastian Zöllner·Xiaoquan Wen·Jonathan K Pritchard
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Abstract

SUMMARY: The program package TreeLD implements a unified approach to association mapping and fine mapping of complex trait loci and a novel approach to visualizing association data, based on an inferred ancestry of the sample. Fundamentally, the TreeLD approach is based on the idea that the evidence for association at a particular position is contained in the ancestral tree relating the sampled chromosomes at that position. TreeLD provides an easy-to-use interface and can be applied to case-control, TDT trio and quantitative trait data.

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AlgorithmsChromosome MappingComputer GraphicsPolymorphism, Single NucleotideQuantitative Trait LociSequence Analysis, DNASoftwareUser-Computer InterfaceJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.

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Sebastian Zöllner, Xiaoquan Wen, Jonathan K Pritchard. 2005-04-26. Association mapping and fine mapping with TreeLD.. https://doi.org/10.1093/bioinformatics%2Fbti453

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