Decrease of kappa-opioid receptor mRNA level in ventral tegmental area of male mice after repeated experience of aggression.

Andrey V Goloshchapov; Maxim L Filipenko; Natalia P Bondar; Natalia N Kudryavtseva; Jan M Van Ree

doi:10.1016/j.molbrainres.2004.11.009

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Decrease of kappa-opioid receptor mRNA level in ventral tegmental area of male mice after repeated experience of aggression.

Andrey V Goloshchapov·Maxim L Filipenko·Natalia P Bondar·Natalia N Kudryavtseva·Jan M Van Ree

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Abstract

Brain opioid systems have been implicated in the regulation of social interaction, including agonistic behaviour. kappa-Opioid receptor B and C mRNA levels were decreased in the ventral tegmental area but not in the nucleus accumbens in male mice with repeated experience of social victories (winners), but not in mice after social defeats (losers) after 10 but not 20 days of confrontations. mu-Opioid receptor mRNA levels were not changed.

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Aggression Analysis of Variance Animals Behavior, Animal Blotting, Northern Cyclophilins Gene Expression Regulation Male Mice Mice, Inbred C57BL Nucleus Accumbens RNA, Messenger Receptors, Opioid, kappa Reverse Transcriptase Polymerase Chain Reaction Social Behavior Ventral Tegmental Area Comparative Study Journal Article Research Support, Non-U.S. Gov't

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Andrey V Goloshchapov, Maxim L Filipenko, Natalia P Bondar, Natalia N Kudryavtseva, Jan M Van Ree. 2005-01-06. Decrease of kappa-opioid receptor mRNA level in ventral tegmental area of male mice after repeated experience of aggression.. https://doi.org/10.1016/j.molbrainres.2004.11.009

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