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PubMed · 15858364

Cyclic stretch induced MAPK phosphorylation stronger than static stretch.

Yuichiro Kanazawa·Jun Nomura·Juni Himeta·Toshikazu Suzuki·Nobuo Suzuki·Shinya Yoshimoto·Masaharu Ichinose
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Abstract

The environment for living organism in space has microgravity and/or hypergravity and/or any kind of mechanical stresses. Cellular response may differ from the variety of mechanical stress. Mitogen-activated protein kinases (MAPKs) pathway is related to various cellular events. In the present study it was investigated the serial measurement of MAPK phosphorylation using western-blotting analysis following with three types of cyclic stretch, static, 0.1 Hz and 0.25 Hz. The result was that induction of MAPK phosphorylation had peaks within 2 to 4 hours and attenuated, while induction of p38 phosphorylation in 0.1 Hz stretch had a peak at 6 hours later and the strongest. Thus, there might be differential cellular response depends upon the frequency of cyclic stretch .

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Blotting, WesternFibroblastsPhosphorylationSignal TransductionStress, MechanicalTime Factorsp38 Mitogen-Activated Protein KinasesJournal Article

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Yuichiro Kanazawa, Jun Nomura, Juni Himeta, Toshikazu Suzuki, Nobuo Suzuki, Shinya Yoshimoto, Masaharu Ichinose. 2004. Cyclic stretch induced MAPK phosphorylation stronger than static stretch.. https://pubmed.ncbi.nlm.nih.gov/15858364/

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