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PubMed · 15860413

Multiple functions of type 10 17beta-hydroxysteroid dehydrogenase.

Song-Yu Yang·Xue-Ying He·Horst Schulz
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Abstract

Human 17beta-hydroxysteroid dehydrogenase type 10 (17beta-HSD10) is a mitochondrial enzyme encoded by the SCHAD gene, which escapes chromosome X inactivation. 17Beta-HSD10/SCHAD mutations cause a spectrum of clinical conditions, from mild mental retardation to progressive infantile neurodegeneration. 17Beta-HSD10/SCHAD is essential for the metabolism of isoleucine and branched-chain fatty acids. It can inactivate 17beta-estradiol and steroid modulators of GABA(A) receptors, and convert 5alpha-androstanediol into 5alpha-dihydrotestosterone (DHT). Certain malignant prostatic epithelial cells contain high levels of 17beta-HSD10, generating 5alpha-DHT in the absence of testosterone. 17Beta-HSD10 has an affinity for amyloid-beta peptide, and might be linked to the mitochondrial dysfunction seen in Alzheimer's disease. This versatile enzyme might provide a new drug target for neuronal excitability control and for intervention in Alzheimer's disease and certain cancers.

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17-Hydroxysteroid Dehydrogenases3-Hydroxyacyl CoA DehydrogenasesAlzheimer DiseaseAnimalsGonadal Steroid HormonesHumansIsoleucineNeurotransmitter AgentsSteroidsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Song-Yu Yang, Xue-Ying He, Horst Schulz. Multiple functions of type 10 17beta-hydroxysteroid dehydrogenase.. https://doi.org/10.1016/j.tem.2005.03.006

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