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Phosphorylation-specific prolyl isomerization: is there an underlying theme?

Gerburg Wulf·Greg Finn·Futoshi Suizu·Kun Ping Lu
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Abstract

The prolyl isomerase Pin1 is a conserved enzyme that is intimately involved in diverse biological processes and pathological conditions such as cancer and Alzheimer's disease. By catalysing cis-trans interconversion of certain motifs containing phosphorylated serine or threonine residues followed by a proline residue (pSer/Thr-Pro), Pin1 can have profound effects on phosphorylation signalling. The structural and functional differences that result from cis-trans isomerization of specific pSer/Thr-Pro motifs probably underlie most, if not all, Pin1-dependent actions. Phosphorylation-dependent prolyl isomerization by Pin1 remains a unique mode for the modulation of signal transduction. Here, we provide an overview of the plethora of regulatory events that involve this unique enzyme, with a particular focus on oncogenic signalling and neurodegeneration.

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Alzheimer DiseaseCell ProliferationHumansIsomerismNIMA-Interacting Peptidylprolyl IsomeraseNeoplasmsPeptidylprolyl IsomerasePhosphorylationPhosphoserinePhosphothreonineProtein ConformationSignal TransductionJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.Review

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Gerburg Wulf, Greg Finn, Futoshi Suizu, Kun Ping Lu. 2005. Phosphorylation-specific prolyl isomerization: is there an underlying theme?. https://doi.org/10.1038/ncb0505-435

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