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PubMed · 15875607

Ezetimibe-induced hyperlipidaemia.

E Doherty·P J Lumb·G Chik·A S Wierzbicki
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Abstract

Ezetimibe is intestinally active cholesterol absorption inhibitor used to reduce low-density lipoprotein-cholesterol levels. This case report describes a novel side effect with this agent: ezetimibe-induced hyperlipidaemia in a patient with statin intolerance and familial combined hyperlipidaemia. Ezetimibe therapy induced an asymptomatic 770% increase in triglycerides (TGs) (3.51-27.1 mmol/l) and a 190% increase in total cholesterol (9.8-18.5 mmol/ 1) secondary to an increase (4.6-25.9 micromol/l; 560%) in hepatic cholesterol (lathosterol) synthesis. This lipid profile resolved 9 months after cessation of ezetimibe therapy. This report shows that ezetimibe may have long-lasting effects in man far exceeding its plasma half-life and that ezetimibe monotherapy can induce a large increase in hepatocyte very-low-density lipoprotein synthesis in rare individuals with a consequent mixed hyperlipidaemia or possibly hypercholesterolaemia depending on the metabolism and clearance of TG-rich lipoproteins.

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Anticholesteremic AgentsAzetidinesCholesterolEzetimibeFemaleHumansHyperlipidemia, Familial CombinedHyperlipidemiasMiddle AgedTriglyceridesCase ReportsJournal Article

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BibTeXRIS

E Doherty, P J Lumb, G Chik, A S Wierzbicki. 2005. Ezetimibe-induced hyperlipidaemia.. https://doi.org/10.1111/j.1368-504x.2005.00423.x

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