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SCHIP: statistics for chromosome interphase positioning based on interchange data.

Sergi Vives·Bradford Loucas·Mariel Vazquez·David J Brenner·Rainer K Sachs·Lynn Hlatky·Michael Cornforth·Javier Arsuaga
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Abstract

MOTIVATION: The position of chromosomes in the interphase nucleus is believed to be associated with a number of biological processes. Here, we present a web-based application that helps analyze the relative position of chromosomes during interphase in human cells, based on observed radiogenic chromosome aberrations. The inputs of the program are a table of yields of pairwise chromosome interchanges and a proposed chromosome geometric cluster. Each can either be uploaded or selected from provided datasets. The main outputs are P-values for the proposed chromosome clusters. SCHIP is designed to be used by a number of scientific communities interested in nuclear architecture, including cancer and cell biologists, radiation biologists and mathematical/computational biologists.

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Chromosome AberrationsChromosome MappingData Interpretation, StatisticalInterphaseModels, GeneticModels, StatisticalSister Chromatid ExchangeSoftwareUser-Computer InterfaceNASA Discipline Radiation HealthNon-NASA CenterJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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Sergi Vives, Bradford Loucas, Mariel Vazquez, David J Brenner, Rainer K Sachs, Lynn Hlatky, Michael Cornforth, Javier Arsuaga. 2005-05-10. SCHIP: statistics for chromosome interphase positioning based on interchange data.. https://doi.org/10.1093/bioinformatics%2Fbti470

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