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PubMed · 15892112

Coding repeats and evolutionary "agility".

Sandrine Caburet·Julie Cocquet·Daniel Vaiman·Reiner A Veitia
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Abstract

The rapid generation of new shapes observed in the living world is the result of genetic variation, especially in "morphological" developmental genes. Many of these genes contain coding tandem repeats. Fondon and Garner have shown that expansions and contractions of these repeats are associated with the great diversity of morphologies observed in the domestic dog, Canis familiaris. In particular, they found that the repeat variations in two genes were significantly associated with changes in limb and skull morphology. These results open the possibility that such a mechanism contributes to the diversity of life.

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AnimalsEvolution, MolecularGene Expression Regulation, DevelopmentalGenetic VariationHumansMorphogenesisTandem Repeat SequencesTranscription FactorsJournal ArticleReview

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Sandrine Caburet, Julie Cocquet, Daniel Vaiman, Reiner A Veitia. 2005. Coding repeats and evolutionary "agility".. https://doi.org/10.1002/bies.20248

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