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IgG neuropathy: an immunoelectron microscopic study.

Jean-Michel Vallat·Laurent Magy·Philippe Sindou·Corinne Magdelaine·Didier Cros
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Abstract

There are many potential mechanisms of peripheral nerve impairment by a monoclonal IgG dysglobulinemia. In this study, using electron microscopy, we observed widening of the myelin lamellae comparable to that commonly described in IgM neuropathies with antimyelin-associated glycoprotein activity. Such features have yet to be described in IgG neuropathies. In addition, we observed deposits of a granular material in the interstitial tissue of the nerve. By immunoelectron microscopy, we demonstrated the presence of the IgG in the lesions of myelin and the endoneurial space. A direct link between monoclonal dysglobulinemia (regardless of type) and polyneuropathy should be confirmed by nerve biopsy, because the result may influence treatment.

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Antibodies, Anti-IdiotypicFemaleHumansImmunoglobulin GMicroscopy, ImmunoelectronMiddle AgedMyelin SheathPolyneuropathiesCase ReportsJournal Article

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BibTeXRIS

Jean-Michel Vallat, Laurent Magy, Philippe Sindou, Corinne Magdelaine, Didier Cros. 2005. IgG neuropathy: an immunoelectron microscopic study.. https://doi.org/10.1093/jnen%2F64.5.386

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