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PubMed · 15892636

Non-steroidal steroid receptor modulators.

Rogier C Buijsman·Pedro H H Hermkens·Rachel D van Rijn·H Thijs Stock·N Miranda Teerhuis
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Abstract

The last ten years much attention has been focused on the finding of non-steroidal ligands for steroidal nuclear receptors for reasons such as diminishing cross-reactivity to eliminate side effect profiles, changing physicochemical properties which might cause different tissue distribution profiles and altering binding modes which influence the binding of cofactors. Compounds with a selective functionality profile are referred to as selective nuclear receptor modulators (e.g., SARMs or SPRMs). In the following paragraphs non-steroidal ligands which have full or partial agonistic activity will be described for the following receptors: PR, GR, AR, LXR and FXR.

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Androgen Receptor AntagonistsAndrogensDNA-Binding ProteinsHumansLigandsLiver X ReceptorsOrphan Nuclear ReceptorsPromoter Regions, GeneticReceptors, AndrogenReceptors, Cytoplasmic and NuclearReceptors, EstrogenReceptors, GlucocorticoidReceptors, ProgesteroneSelective Estrogen Receptor ModulatorsTranscription FactorsReceptor, Farnesoid X-ActivatedJournal ArticleReview

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Rogier C Buijsman, Pedro H H Hermkens, Rachel D van Rijn, H Thijs Stock, N Miranda Teerhuis. 2005. Non-steroidal steroid receptor modulators.. https://doi.org/10.2174/0929867053764671

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