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PubMed · 15896738

A putative nuclear function for mammalian Staufen.

Michael A Kiebler·Ralf-Peter Jansen·Ralf Dahm·Paolo Macchi
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Abstract

In addition to its role in rRNA processing and ribosome assembly, the nucleolus plays a part in the assembly of non-ribosomal ribonucleoprotein particles (RNPs) that are destined for cytoplasmic RNA delivery. Recent evidence indicates that mammalian Staufen2, a brain-specific RNA-binding protein involved in RNA localization, can--at least transiently--enter the nucleolus. Therefore, the assembly of Staufen2 into transport-competent RNPs might occur in the nucleus before their export into the cytoplasm. This could provide new insights into the mechanisms of subcellular RNA localization.

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Active Transport, Cell NucleusAdenosine DeaminaseAnimalsCell NucleolusModels, BiologicalProtein IsoformsRNARNA-Binding ProteinsRibonucleoproteinsJournal ArticleResearch Support, Non-U.S. Gov't

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Michael A Kiebler, Ralf-Peter Jansen, Ralf Dahm, Paolo Macchi. 2005. A putative nuclear function for mammalian Staufen.. https://doi.org/10.1016/j.tibs.2005.03.005

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