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PubMed · 15897998

Eagle effect in Corynebacterium diphtheriae.

Lucia Grandière-Pérez·Cedric Jacqueline·Virginie Lemabecque·Olivier Patey·Gilles Potel·Jocelyne Caillon
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Abstract

The in vivo relevance of the paradoxical bactericidal effect (the Eagle effect) is not evident. We found in vitro a paradoxical bactericidal effect of amoxicillin on 2 strains of nontoxigenic Corynebacterium diphtheriae. Then, using an experimental rabbit model of endocarditis, we evaluated the in vivo relevance of this phenomenon. Rabbits were assigned to the following groups: no treatment (control group), continuous amoxicillin infusion simulating a dosage of 200 mg/kg/day in humans, and continuous amoxicillin infusion simulating a dosage of 20 mg/kg/day in humans. The low dosage (20 mg/kg/day) was significantly more effective than the high dosage (200 mg/kg/day) against both strains (P<.025), confirming the paradoxical bactericidal effect observed in vitro.

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AmoxicillinAnimalsAnti-Bacterial AgentsCorynebacterium InfectionsCorynebacterium diphtheriaeDiphtheriaDose-Response Relationship, DrugEndocarditis, BacterialFemaleMicrobial Sensitivity TestsRabbitsJournal Article

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Lucia Grandière-Pérez, Cedric Jacqueline, Virginie Lemabecque, Olivier Patey, Gilles Potel, Jocelyne Caillon. 2005-05-10. Eagle effect in Corynebacterium diphtheriae.. https://doi.org/10.1086/430350

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