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PubMed · 15898713

Transferrin-mediated gold nanoparticle cellular uptake.

Pei-Hui Yang·Xuesong Sun·Jen-Fu Chiu·Hongzhe Sun·Qing-Yu He
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Abstract

Targeted drug delivery is an important research area in specific therapy. Transferrin-conjugated nanoparticles are an attractive formulation as a vehicle for specific cellular uptake and targeted drug delivery. In this report, atomic force microscopy imaging was used to visualize the process of cellular uptake of transferrin-coupled gold nanoparticles on the surfaces of live cells for the first time. High-resolution images were captured, showing the endocytosis of transferrin-conjugated nanoparticles taking place during the process of internalization. This specific transferrin-mediated nanoparticle uptake was validated by confocal scanning imaging and transferrin competition experiments.

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Biological TransportCell Line, TumorGoldHumansMicroscopy, Atomic ForceMicroscopy, ConfocalNanostructuresTransferrinJournal ArticleResearch Support, Non-U.S. Gov't

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Pei-Hui Yang, Xuesong Sun, Jen-Fu Chiu, Hongzhe Sun, Qing-Yu He. Transferrin-mediated gold nanoparticle cellular uptake.. https://doi.org/10.1021/bc049775d

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