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PubMed · 15903455

Selective advantage for conservative viruses.

Yisroel Brumer·Eugene I Shakhnovich
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Abstract

In this article we study the full semiconservative treatment of a model for the coevolution of a virus and an adaptive immune system. Regions of viability are calculated for both conservatively and semiconservatively replicating viruses interacting with a realistic semiconservatively replicating immune system. The conservative virus is found to have a selective advantage in the form of an ability to survive in regions with a wider range of mutation rates than its semiconservative counterpart, as well as an increased replication rate where both species can survive. This may help explain the existence of a rich range of viruses with conservatively replicating genomes, a trait that is found nowhere else in nature.

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Adaptation, PhysiologicalAnimalsBiological EvolutionHost-Parasite InteractionsHumansImmune SystemImmunity, InnateModels, BiologicalSelection, GeneticVirus ReplicationVirusesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.

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Yisroel Brumer, Eugene I Shakhnovich. 2005-03-08. Selective advantage for conservative viruses.. https://doi.org/10.1103/physreve.71.031903

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