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A method for identifying external control sites in metabolic systems.

B Crabtree
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Abstract

A graphic method is presented for the identification of control sites in a metabolic system. This method is based on the matrix method for calculating net sensitivities developed by Crabtree and Newsholme (Biochem. J. 247: 113-120, 1987) and avoids the misidentification of control sites that can result from a simple inspection of a system. The method is easily adapted for analysis by computer and may be used for preliminary investigations of metabolic systems to identify potential control sites for further more quantitative investigations.

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B Crabtree. 1992. A method for identifying external control sites in metabolic systems.. https://doi.org/10.1152/ajpregu.1992.262.5.r806

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