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Type I polyketide synthases may have evolved through horizontal gene transfer.

Aurélien Ginolhac·Cyrille Jarrin·Patrick Robe·Guy Perrière·Timothy M Vogel·Pascal Simonet·Renaud Nalin
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Abstract

Type I polyketide synthases (PKSI) are modular multidomain enzymes involved in the biosynthesis of many natural products of industrial interest. PKSI modules are minimally organized in three domains: ketosynthase (KS), acyltransferase (AT), and acyl carrier protein. The KS domain phylogeny of 23 PKSI clusters was determined. The results obtained suggest that many horizontal transfers of PKSI genes have occurred between actinomycetales species. Such gene transfers may explain the homogeneity and the robustness of the actinomycetales group since gene transfers between closely related species could mimic patterns generated by vertical inheritance. We suggest that the linearity and instability of actinomycetales chromosomes associated with their large quantity of genetic mobile elements have favored such horizontal gene transfers.

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AcyltransferasesAmphotericin BBacterial ProteinsEvolution, MolecularGene Transfer TechniquesGene Transfer, HorizontalGenes, BacterialMacrolidesModels, GeneticMultigene FamilyNatamycinNystatinPhylogenyPolyketide SynthasesProtein Structure, TertiaryJournal ArticleResearch Support, Non-U.S. Gov't

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Aurélien Ginolhac, Cyrille Jarrin, Patrick Robe, Guy Perrière, Timothy M Vogel, Pascal Simonet, Renaud Nalin. 2005-05-16. Type I polyketide synthases may have evolved through horizontal gene transfer.. https://doi.org/10.1007/s00239-004-0161-1

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