Ageing and PARP.

Alexander Bürkle; Jörg Diefenbach; Christine Brabeck; Sascha Beneke

doi:10.1016/j.phrs.2005.02.008

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Ageing and PARP.

Alexander Bürkle·Jörg Diefenbach·Christine Brabeck·Sascha Beneke

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Abstract

Poly(ADP-ribosyl)ation, which is the posttranslational modification of proteins with poly(ADP-ribose), is catalysed by poly(ADP-ribose) polymerases. DNA-strand break induced catalytic activation of two PARP isoforms, namely PARP-1 and -2, are in involved in DNA base-excision repair and other repair pathways. A body of correlative data suggests a link between DNA-damage induced poly(ADP-ribosyl)ation and mammalian longevity. This notion was reinforced by recently published evidence for interactions between PARP-1 and the Werner syndrome protein, deficiency of which causes premature ageing in humans. Recent research on PARPs and poly(ADP-ribose) provides several candidate mechanisms through which poly(ADP-ribosyl)ation might contribute to keeping the ageing process at slow pace.

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Aging Animals DNA Damage DNA Repair Humans Longevity Poly(ADP-ribose) Polymerases Proteins Journal Article Research Support, Non-U.S. Gov't Review

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Alexander Bürkle, Jörg Diefenbach, Christine Brabeck, Sascha Beneke. 2005. Ageing and PARP.. https://doi.org/10.1016/j.phrs.2005.02.008

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