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c-Jun interacts with phospholipids and c-Fos at the interface.

Maximiliano Del Boca·Beatriz L Caputto·Bruno Maggio·Graciela A Borioli
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Abstract

We describe c-Jun, a widely studied transcription factor that participates in cell proliferation, differentiation, and tumorigenesis, as amphitropic. We show that c-Jun forms stable monolayers and interacts favorably, although in a nonselective manner, with phospholipids at the interface. The surface activity of c-Jun, together with that of c-Fos, its common partner in AP-1 transcription heterodimers, drives interfacial complex formation. We show that AP-1 is very stable at the air-water interface and suggest that AP-1 may not be substantially formed in solution as a stable equimolar association of both proteins.

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Binding, CompetitivePhospholipidsProtein BindingProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-junSurface PropertiesTranscription Factor AP-1Journal ArticleResearch Support, Non-U.S. Gov't

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BibTeXRIS

Maximiliano Del Boca, Beatriz L Caputto, Bruno Maggio, Graciela A Borioli. 2005-07-01. c-Jun interacts with phospholipids and c-Fos at the interface.. https://doi.org/10.1016/j.jcis.2005.01.069

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