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Peripheral vascular endothelial function in essential hyperhidrosis.

Ali Metin Esen·Irfan Barutcu·Semsettin Karaca·Dayimi Kaya·Mustafa Kulac·Ozlem Esen·Osman Karakaya·Mehmet Melek·Ersel Onrat·Atac Celik·Celal Kilit
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Abstract

BACKGROUND: Essential hyperhidrosis, a disorder of the eccrine sweat glands, is associated with sympathetic overactivity and the aim of the present study was to determine endothelium-dependent vasodilator function in patients with this condition. METHODS AND RESULTS: Using high-resolution ultrasound, the diameter of the brachial artery at rest and during reactive hyperemia (flow-mediated dilatation, %FMD endothelial-dependent stimulus to vasodilatation), as well as after sublingual administration of nitroglycerin (%NTG endothelium-independent vasodilatation) was measured in 18 subjects (mean age 27+/-5 years) with essential hyperhidrosis and 24 healthy control subjects (mean age 29+/-5 years). Baseline brachial artery diameter and FMD were comparable in both groups (BAD: 4.1+/-0.7 mm vs 4.3+/-0.5 mm (control), p = 0.8; FMD: 5.6+/-1.9% vs 6.7+/-2.2%, p=0.1). The time-averaged flow velocity during peak reactive hyperemia was similar in the 2 groups (75+/-11 cm/s vs 72+/-10 cm/s, p = 0.5), nor did NTG-induced dilatation in the patients with essential hyperhidrosis differ significantly from that in healthy control subjects (12.8+/-2.7% vs 14.0+/-3.6%, p = 0.3). CONCLUSION: These findings suggest that endothelium-dependent dilatation of large conduit arteries is preserved in essential hyperhidrosis and it seems to be a localized disorder of the eccrine sweat glands rather than a generalized disorder involving vascular endothelium.

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AdultBrachial ArteryEndothelium, VascularFemaleHumansHyperhidrosisMaleNitroglycerinUltrasonographyVasodilationVasodilator AgentsJournal Article

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Ali Metin Esen, Irfan Barutcu, Semsettin Karaca, Dayimi Kaya, Mustafa Kulac, Ozlem Esen, Osman Karakaya, Mehmet Melek, Ersel Onrat, Atac Celik, Celal Kilit. 2005. Peripheral vascular endothelial function in essential hyperhidrosis.. https://doi.org/10.1253/circj.69.707

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