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Cell microarrays and RNA interference chip away at gene function.

Douglas B Wheeler·Anne E Carpenter·David M Sabatini
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Abstract

The recent development of cell microarrays offers the potential to accelerate high-throughput functional genetic studies. The widespread use of RNA interference (RNAi) has prompted several groups to fabricate RNAi cell microarrays that make possible discrete, in-parallel transfection with thousands of RNAi reagents on a microarray slide. Though still a budding technology, RNAi cell microarrays promise to increase the efficiency, economy and ease of genome-wide RNAi screens in metazoan cells.

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AnimalsCells, CulturedGene SilencingGenomicsHumansImage Processing, Computer-AssistedOligonucleotide Array Sequence AnalysisRNA InterferenceJournal ArticleReview

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Douglas B Wheeler, Anne E Carpenter, David M Sabatini. 2005. Cell microarrays and RNA interference chip away at gene function.. https://doi.org/10.1038/ng1560

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