Testis-specific histone H3 expression in somatic cells.

Jérôme Govin; Cécile Caron; Sophie Rousseaux; Saadi Khochbin

doi:10.1016/j.tibs.2005.05.001

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Testis-specific histone H3 expression in somatic cells.

Jérôme Govin·Cécile Caron·Sophie Rousseaux·Saadi Khochbin

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Abstract

Histone variants functionally differentiate individual nucleosomes and, hence, act as key regulators of chromatin structure and function. Large-scale proteomic projects are now valuable sources of histone-variant discovery, showing, in particular, that somatic mammalian cells express a larger panel of histone H3 variants than previously thought, including testis-specific variants and as yet uncharacterized species. These data also suggest a tight relationship between the complexity of histone-variant expression and physiopathological states of the cells.

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Amino Acid Sequence Animals Cells Gene Expression Histones Humans Male Molecular Sequence Data Nucleosomes Organ Specificity Testis Journal Article Research Support, Non-U.S. Gov't Review

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Jérôme Govin, Cécile Caron, Sophie Rousseaux, Saadi Khochbin. 2005. Testis-specific histone H3 expression in somatic cells.. https://doi.org/10.1016/j.tibs.2005.05.001

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