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New insights into E-protein function in lymphocyte development.

Adam Lazorchak·Mary Elizabeth Jones·Yuan Zhuang
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Abstract

Lymphocyte development has long served as an experimental paradigm, revealing fundamental mechanisms of gene regulation and cellular differentiation in mammals. The study of E-protein-mediated transcriptional regulation in lymphocyte development provides a means to address these mechanistic issues. Both genetic and biochemical studies have defined many important regulatory events during lymphocyte development that are mediated by E-proteins. The E2A gene, one of the three known E-protein genes in mammals, has a particularly important role in B-lymphocyte development. Major progress has been made in recent years towards understanding the physiological targets of E2A during B-lymphocyte development. Most notably, new insights have been gained regarding the role of E2A in controlling lineage commitment and V(D)J recombination. This Review focuses primarily on E2A-mediated gene regulation during B-lymphocyte development.

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AnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationCell LineageDNA-Binding ProteinsGene Expression RegulationHumansImmunoglobulin kappa-ChainsLymphocytesTranscription FactorsJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, P.H.S.Review

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Adam Lazorchak, Mary Elizabeth Jones, Yuan Zhuang. 2005. New insights into E-protein function in lymphocyte development.. https://doi.org/10.1016/j.it.2005.03.011

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