Microdamage in bone: surface analysis and radiological detection.

Raman Parkesh; T Clive Lee; Thorfinnur Gunnlaugsson; Wolfgang Gowin

doi:10.1016/j.jbiomech.2005.04.003

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Microdamage in bone: surface analysis and radiological detection.

Raman Parkesh·T Clive Lee·Thorfinnur Gunnlaugsson·Wolfgang Gowin

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Abstract

Microdamage accumulation leads to reduced bone strength and fracture. Intact, damaged and Rose Bengal stained cortical bone specimens were studied using SEM and EDXA imaging. SEM coupled with EDXA studies showed selective labelling of surface damage due to binding of dye at free lattice sites. A series of novel iodinated X-ray contrast agent were synthesised. These agents demonstrated excellent stability, water solubility and lack of atropisomerism. Preliminary imaging studies, using cone-beam mu-CT, demonstrated their ability to provide visible contrast in the solid state on bone surfaces.

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Absorptiometry, Photon Animals Bone Density Bone Remodeling Cattle Contrast Media Fractures, Bone Iodine Radionuclide Imaging Stress, Mechanical Journal Article Research Support, Non-U.S. Gov't

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Raman Parkesh, T Clive Lee, Thorfinnur Gunnlaugsson, Wolfgang Gowin. 2005-05-31. Microdamage in bone: surface analysis and radiological detection.. https://doi.org/10.1016/j.jbiomech.2005.04.003

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