Linkage disequilibrium maps and association mapping.

Newton E Morton

doi:10.1172/jci25032

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Linkage disequilibrium maps and association mapping.

Newton E Morton

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Abstract

The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence. Recently, polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD) the most powerful tool for localization. The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative methods for gene localization, are briefly described.

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Databases, Genetic Genetic Predisposition to Disease Genome, Human Humans Linkage Disequilibrium Physical Chromosome Mapping Polymorphism, Single Nucleotide Journal Article Research Support, Non-U.S. Gov't Review

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Newton E Morton. 2005. Linkage disequilibrium maps and association mapping.. https://doi.org/10.1172/jci25032

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