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Professional antigen-presentation function by human gammadelta T Cells.

Marlène Brandes·Katharina Willimann·Bernhard Moser
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Abstract

Human gammadelta T cells are considered to play a vital role in protective immunity through cytokine secretion and cytotoxic activity. We report that cells expressing the Vgamma2Vdelta2+-T cell receptor (Vdelta2+ T cells) also display principal characteristics of professional antigen-presenting cells such as dendritic cells. Thus, when activated, these cells efficiently processed and displayed antigens and provided co-stimulatory signals sufficient for strong induction of naïve alphabeta T cell proliferation and differentiation. We suggest that, upon microbial activation, Vdelta2+ T cells participate in the induction of adaptive immune responses and that these cells may be a useful tool in vaccine development and immunotherapy.

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Antigen PresentationAntigen-Presenting CellsBacterial ToxinsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell DifferentiationCell PolarityDendritic CellsEnterotoxinsHLA-DR AntigensHistocompatibility Antigens Class IIHumansImmunity, ActiveLymphocyte ActivationReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSuperantigensT-Lymphocyte SubsetsT-Lymphocytes, CytotoxicTetanus ToxoidTuberculinJournal ArticleResearch Support, Non-U.S. Gov't

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Marlène Brandes, Katharina Willimann, Bernhard Moser. 2005-06-02. Professional antigen-presentation function by human gammadelta T Cells.. https://doi.org/10.1126/science.1110267

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